<p>CYLD Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Regulating NDRG1</p>
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TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells
The TP53-induced glycolysis and apoptosis regulator (TIGAR) is the protein product of the p53 target gene, C12orf5. TIGAR blocks glycolysis and promotes cellular metabolism via the pentose phosphate pathway; it promotes the production of cellular nicotinamide adenine dinucleotide phosphate (NADPH), which leads to enhanced scavenging of intracellular reactive oxygen species, and inhibition of ox...
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ژورنال
عنوان ژورنال: Cancer Management and Research
سال: 2020
ISSN: 1179-1322
DOI: 10.2147/cmar.s268216